ATE58898T1 - Antiarrhythmische agenzien. - Google Patents

Antiarrhythmische agenzien.

Info

Publication number
ATE58898T1
ATE58898T1 AT87306922T AT87306922T ATE58898T1 AT E58898 T1 ATE58898 T1 AT E58898T1 AT 87306922 T AT87306922 T AT 87306922T AT 87306922 T AT87306922 T AT 87306922T AT E58898 T1 ATE58898 T1 AT E58898T1
Authority
AT
Austria
Prior art keywords
agents
antiarhythmic
alkyl
different
same
Prior art date
Application number
AT87306922T
Other languages
German (de)
English (en)
Inventor
John Edward Glyn Kemp
Peter Edward Cross
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Application granted granted Critical
Publication of ATE58898T1 publication Critical patent/ATE58898T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
AT87306922T 1986-08-09 1987-08-05 Antiarrhythmische agenzien. ATE58898T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868619472A GB8619472D0 (en) 1986-08-09 1986-08-09 Anti-arrhythmia agents
EP87306922A EP0257864B1 (en) 1986-08-09 1987-08-05 Antiarrhythmic agents

Publications (1)

Publication Number Publication Date
ATE58898T1 true ATE58898T1 (de) 1990-12-15

Family

ID=10602501

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87306922T ATE58898T1 (de) 1986-08-09 1987-08-05 Antiarrhythmische agenzien.

Country Status (11)

Country Link
US (1) US4797401A (en])
EP (1) EP0257864B1 (en])
JP (1) JPS6344572A (en])
AT (1) ATE58898T1 (en])
DE (1) DE3766570D1 (en])
DK (1) DK169129B1 (en])
ES (1) ES2031509T3 (en])
GB (1) GB8619472D0 (en])
GR (1) GR3001231T3 (en])
IE (1) IE60030B1 (en])
PT (1) PT85506B (en])

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
US5051423A (en) * 1988-07-13 1991-09-24 Schering Ag Derivatized alkanolamines as cardiovascular agents
DE3933163A1 (de) * 1988-10-27 1990-05-03 Toyoda Gosei Kk Zylindrische daempfungsbuchse
US5033872A (en) * 1989-09-06 1991-07-23 Toyoda Gosei Co., Ltd. Bushing
US5051422A (en) * 1989-09-15 1991-09-24 Schering Ag 2-substituted-1(4)-aryl piperazines and the process for their preparation
US5215989A (en) * 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US5112824A (en) * 1989-12-08 1992-05-12 Merck & Co., Inc. Benzofuran compounds as class III antiarrhythmic agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
US6083991A (en) 1997-06-04 2000-07-04 University Of Florida Research Foundation, Inc. Anti-arrhythmic composition and methods of treatment
CN1129581C (zh) 1998-09-22 2003-12-03 山之内制药株式会社 氰基苯基衍生物
CN110156729B (zh) * 2019-05-14 2022-12-06 浙江大学 一种苯基哌嗪类ube2f小分子抑制剂及其合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB997166A (en) * 1961-07-14 1965-07-07 May & Baker Ltd N-phenylpiperazine derivatives
BE654017A (en]) * 1963-04-04 1965-04-06
ES291187A1 (es) * 1963-04-04 1964-01-16 American Cyanamid Co Un procedimiento para preparar piperazinas sustituidas
US3331845A (en) * 1963-04-04 1967-07-18 American Cyanamid Co 1-substituted-4-substituted amino alkylene piperazines
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof
US3822266A (en) * 1968-12-24 1974-07-02 Hoffmann La Roche (3-(1-piperazinyl)-2-hydroxy-propoxy)acetanilides
US3758692A (en) * 1969-04-14 1973-09-11 Mead Johnson & Co Ylamines sympathomimetic process and compositions employing sulfonamidophenalk
BE757005A (fr) * 1969-10-02 1971-04-02 Bristol Myers Co Phenethanolamines substituees et procede pour leur preparation
US3764602A (en) * 1969-12-04 1973-10-09 Hoffmann La Roche 3-(4-phenyl-1 2, 6 di keto piperazinyl)-2-hydroxy-propoxy)-aniline
US3930004A (en) * 1970-11-10 1975-12-30 Pfizer Method of using phenoxypropanolpiperazine compounds to lower blood pressure
GB1361863A (en) * 1972-09-25 1974-07-30 Pfizer Ltd Piperazine derivatives their preparation and pharmaceutical compositions containing them
FR2515648A1 (fr) * 1981-11-03 1983-05-06 Cortial Nouvelles (phenyl-4 piperazinylethyl)-2 anilines, leur methode de preparation et leur application therapeutique
PH23283A (en) * 1986-02-26 1989-06-30 Eisai Co Ltd Piperidine derivative, pharmaceutical composition containing the same and method of use thereof

Also Published As

Publication number Publication date
IE60030B1 (en) 1994-05-18
GB8619472D0 (en) 1986-09-17
JPH0567150B2 (en]) 1993-09-24
DK411687A (da) 1988-04-28
EP0257864B1 (en) 1990-12-05
PT85506B (pt) 1990-06-29
EP0257864A1 (en) 1988-03-02
IE872120L (en) 1988-02-09
US4797401A (en) 1989-01-10
JPS6344572A (ja) 1988-02-25
PT85506A (en) 1987-09-01
ES2031509T3 (es) 1992-12-16
DK169129B1 (da) 1994-08-22
GR3001231T3 (en) 1992-07-30
DK411687D0 (da) 1987-08-07
DE3766570D1 (de) 1991-01-17

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee